Paddy had been drinking at his local pub all day and most of the night, celebrating St Patrick's Day.

Mick, the bartender says, 'You'll not be drinking anymore tonight, Paddy'.

Paddy replies, 'OK Mick, I'll be on my way then'. Paddy spins around on his stool and steps off. He falls flat on his face.'Damn' he says and pulls himself up by the stool and dusts himself off.

He takes a step towards the door and falls flat on his face, 'oh bloody damn!' He looks to the doorway and thinks to himself that if he can just get to the door and some fresh air he'll be fine.He belly crawls to the door and shimmies up to the door frame.

He sticks his head outside and takes a deep breath of fresh air, feels much better and takes a step out onto the sidewalk and falls flat on his face.'Bi' Jesus… I'm in bloody trouble,' he says.

He can see his house just a few doors down, and crawls to the door, hauls himself up the door frame, opens the door and shimmies inside.

He takes a look up the stairs and says 'No bloody way....'He crawls up the stairs to his bedroom door and says 'I can make it to the bed'.

He takes a step into the room and falls flat on his face. He says 'damn it' and falls into bed.

The next morning, his wife, Jess, comes into the room carrying a cup of coffee and says, 'Get up Paddy. Did you have a bit to drink last night ? 'Paddy says, 'I did, Jess. I was bloody pissed. But how did you know?''

Mick phoned .. . . You left your wheelchair at the pub.'

No, but they're telling you enough to make you jump off the Trump wagon and drive you to a candidate they prefer so that it is easier to defeat him.
The swamp chooses who to support based on who they need to beat. Sometimes that is a conservative that has to lose because beating him is too hard, like Trump.

Let me know when Trump can give us 8 years of a Republican presidency.

In the mean time, you can actually pay attention to what DeSantis is saying and doing without having Big Daddy Donald telling you what to think about him.

I'm still waiting for someone to explain how any republican can win in the general.   Please explain how a republican can win in PA, MI, WI, GA or AZ?   How about the blue shithole states?

  There has been no election reform in those states.  So with the current electoral map, someone please explain how republicans win?

  I'll wait.

Easy.  Run a quality candidate not named TRUMP!

This is not a clown show.  It’s a few representatives doing what they’ve been elected to do. 

When was the last time we saw the whole house debate anything?   The politburo scheme that the house has devolved into needs shaking up. 

McCarthy is responsible.  He sat back awaiting his turn without any policy whatsoever.  Now his back is against the wall.  He has to decide on the will of the voters or his loyalty to the Uniparty.

In principle I’m not against the 20. I like kicking the swamp as much as anyone. But the 20 never presented their own candidate who could successfully challenge McCarthy. Jim Jordan would be great (Chip Roy would be better, and Clay Higgins would be my top choice) but Jordan never ran for it, tried to Caucus for it, or made his own case. Fine.  So instead of presenting their own candidate, they wanted concessions. Again, great. From what I gather (and it’s impossible to know all the facts) McCarthy has agreed to those terms. So if that’s true (and I can’t know for sure), what is the end game? 

You don’t engage in battle without an definable objective, and sufficient weaponry. I sense the 20 have neither. Sometimes you have to lick your wounds and come back to fight the next fight.

That's a non-trivial question. Your answer is in chapter 5 of Molecular Biology of the Cell, among other texts. The 4th edition is online here:
https://www.ncbi.nlm.nih.gov/books/NBK21054/
But the NIH doesn't allow its contents to be browsed - only searched. Fortunately I have a Kindle copy of the 6th edition (they release new editions about once every ten years, it is considered among the best texts on the subject) and here is what the start of Chapter 5 says:

Chapter 5: DNA Replication, Repair, and Recombination

The ability of cells to maintain a high degree of order in a chaotic universe depends upon the accurate duplication of vast quantities of genetic information carried in chemical form as DNA. This process, called DNA replication, must occur before a cell can produce two genetically identical daughter cells. Maintaining order also requires the continued surveillance and repair of this genetic information, because DNA inside cells is repeatedly damaged by chemicals and radiation from the environment, as well as by thermal accidents and reactive molecules generated inside the cell. In this chapter, we describe the protein machines that replicate and repair the cell’s DNA. These machines catalyze some of the most rapid and accurate processes that take place within cells, and their mechanisms illustrate the elegance and efficiency of cell chemistry.
While the short-term survival of a cell can depend on preventing changes in its DNA, the long-term survival of a species requires that DNA sequences be changeable over many generations to permit evolutionary adaptation to changing circumstances. We shall see that despite the great efforts that cells make to protect their DNA, occasional changes in DNA sequences do occur. Over time, these changes provide the genetic variation upon which selection pressures act during the evolution of organisms.

We begin this chapter with a brief discussion of the changes that occur in DNA as it is passed down from generation to generation. Next, we discuss the cell mechanisms—DNA replication and DNA repair—that are responsible for minimizing these changes. Finally, we consider some of the most intriguing pathways that alter DNA sequences—in particular, those of DNA recombination including the movement within chromosomes of special DNA sequences called transposable elements.

THE MAINTENANCE OF DNA SEQUENCES
Although, as just pointed out, occasional genetic changes enhance the long-term survival of a species through evolution, the survival of the individual demands a high degree of genetic stability. Only rarely do the cell’s DNA-maintenance processes fail, resulting in permanent change in the DNA. Such a change is called a mutation, and it can destroy an organism if it occurs in a vital position in the DNA sequence.

Mutation Rates Are Extremely Low
The mutation rate, the rate at which changes occur in DNA sequences, can be determined directly from experiments carried out with a bacterium such as Escherichia coli—a resident of our intestinal tract and a commonly used laboratory organism (see Figure 1–24). Under laboratory conditions, E. coli divides about once every 30 minutes, and a single cell can generate a very large population— several billion—in less than a day. In such a population, it is possible to detect the small fraction of bacteria that have suffered a damaging mutation in a particular gene, if that gene is not required for the bacterium’s survival. For example, the mutation rate of a gene specifically required for cells to use the sugar lactose as an energy source can be determined by growing the cells in the presence of a different sugar, such as glucose, and testing them subsequently to see how many have lost the ability to survive on a lactose diet. The fraction of damaged genes underestimates the actual mutation rate because many mutations are silent (for example, those that change a codon but not the amino acid it specifies, or those that change an amino acid without affecting the activity of the protein coded for by the gene). After correcting for these silent mutations, one finds that a single gene that encodes an average-sized protein (~10^3 coding nucleotide pairs) accumulates a mutation (not necessarily one that would inactivate the protein) approximately once in about 10^6 bacterial cell generations. Stated differently, bacteria display a mutation rate of about three nucleotide changes per 10^10 nucleotides per cell generation.

Recently, it has become possible to measure the germ-line mutation rate directly in more complex, sexually reproducing organisms such as humans. In this case, the complete genomes from a family—parents and offspring—were directly sequenced, and a careful comparison revealed that approximately 70 new single-nucleotide mutations arose in the germ lines of each offspring. Normalized to the size of the human genome, the mutation rate is one nucleotide change per 10^8 nucleotides per human generation. This is a slight underestimate because some mutations will be lethal and will therefore be absent from progeny; however, because relatively little of the human genome carries critical information, this consideration has only a small effect on the true mutation rate. It is estimated that approximately 100 cell divisions occur in the germ line from the time of conception to the time of production of the eggs and sperm that go on to make the next generation. Thus, the human mutation rate, expressed in terms of cell divisions (instead of human generations), is approximately 1 mutation/10^10 nucleotides/cell division.

Although E. coli and humans differ greatly in their modes of reproduction and in their generation times, when the mutation rates of each are normalized to a single round of DNA replication, they are both extremely low and within a factor of three of each other. We shall see later in the chapter that the basic mechanisms that ensure these low rates of mutation have been conserved since the very early history of cells on Earth.
...

We aren't anti-Trump because we don't like him. We love the guy and what he did. We just don't think this country can survive a further onslaught from the left another Trump campaign/presidency will bring. The country is on the ropes as it is with voter fraud, corrupt politicians, inflation, "foreign aid", etc. The GOP is afraid to fix it, and they won't support Trump. Any Republican candidate is going to get hit hard. It will be a nuclear attack if it's Trump. We can't survive that, no matter how much we want it.

People intent on finding something, anything to attack Donald Trump will find it and satisfy their loathing.

You don’t do that. You know I supported trump, but he’s no longer thinking about the country.  It’s always all about him, even if he pours gasoline on the conservative candidates who don’t bow on bended knee to him.