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Messages - Steingar

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1
Spin Zone / Re: so NOW the government cares about the flu?
« on: September 18, 2020, 06:26:38 AM »
I do wish governments were a bit more judicious in which businesses they deem important enough stay open. Here they allowed tattoo parlors and barbers, I think because part of their licensing involves training in asepsis and hygiene.  There are still some common sense measures that would have allowed a lot more businesses to stay open longer.  But at the end of the day we do have ourselves to blame, we elect these people.

2
Spin Zone / Re: POA MC Job
« on: September 17, 2020, 05:12:21 PM »
I offered (just to give back).  I doubt they'll take me up on it though. I don't really want to do it, but I have been on the site a long time and feel a bit of responsibility.  The Ted doesn't even have an airplane anymore, Odin only knows the next time he'll fly. I think Mari is retired and no longer flies either.  Personally I think the guys charge of an aviation board should be active pilots.

3
Spin Zone / Re: so NOW the government cares about the flu?
« on: September 17, 2020, 05:09:52 PM »
Nothing guarantees you won't get influenza.  But if you mask up, social distance, and keep your hands clean your chances of contracting it go down monumentally.  Heck, Mrs. Steingar had full-blown influenza a couple years back and I didn't get it.

4
The founders didn't know about the internet, so should we not have free speech?  I think you are one of the most clueless people I know.
The Founders know all about the media, which included newspapers as the time.  The internet is nothing more than an extension of what they had at the time. I think had they known that the government could stop the spread of plagues they might have thought about things differently.  Personally, I think your much vaunted freedom ends where you can transmit a potentially lethal disease to me, and I suspect the founders might have thought likewise.  And YOU are the most clueless fellow I know.  While my spouse likes you, I suspect she'd agree.

5
"Powerless to act".   :o

 Ever opened a history book?   Ever read about what led up to the declaration of Independence and the Constitution?  Do you even understand the concept that our rights are not derived from government?   Do you understand why there are checks and balances built into the constitution?

Sadly. Lots of people are idiots like you and can’t figure out that they should take the steps suggested by the medical community to stop the spread of infectious disease. They need the government to force them to do so. In the future I think the government will be unable to do so, and disease will spread. The Founders didn’t know about the germ theory of disease, and didn't know what viruses were. Had they I suspect they’d have written things a bit differently.

6
Spin Zone / Re: What really is known about COVID19?
« on: September 17, 2020, 02:49:54 PM »
To this day I only know of a couple antiviral treatments. Gancyclovir for herpes viruses, antiretrovirals for HIV, and tamiflu. There’s the stuff made against SARS that’s supposed to work on COVID. There just aren’t that many. They’re really hard to make.

7
Published in the Medical Journal of Australia.  Nobel was 23 years after discovery.  And they had a long hard road to acceptance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283743/Now THAT'S dedication.  And shows what it takes to overcome professional skepticism.  Publishing =/= acceptance of findings.

There's often a long stretch between the discovery and the Nobel. Sir John Gurdon's took 50 years! That said, I hadn't remembered they published in an obscure Australian Journal (which that is).  I can see why it didn't get immediate traction.  Thank you.

8
You claim to be a smart guy... can't you think of anything the Government can do without a lockdown?

Honestly, I can't think of a thing that doesn't violate the Constitution's prohibitions concerning freedom of assembly and freedom of expression.  I never thought any of this was constitutional, I just was hoping it'd get a judicial pass, sort of like police DUI checkpoints.  Dead folks have the greatest liberty, but I don't think we really want to go down that road. This won't be the last bad virus to set up shop in humans, I promise you.  If our precedent is that our leaders are powerless to act, we could wind up with some serious catastrophes in the future.

9
Spin Zone / Re: What really is known about COVID19?
« on: September 17, 2020, 11:47:24 AM »
Shoot.  We know exactly what it is and its genome sequence.  How hard would it be to find a magic bullet toxin that attacks exactly that genome sequence and nothing else?  A nicely blueprinted toxin.  Seems pretty easy.  We do it in software all the time, and we call them (ta da!) virus scanners.  Blueprint the virus, watch for it in emails, and then eliminate it when found.  Easy peasy.  Now why can't we do that for real viruses?

Have at it. Actually, we can develop stuff like that.  RNAi will silence any viral RNAs.  Crispr/Cas can cut the viral genome.  Problem is in delivery, getting those reagents to the affected cells as they're affected.  Anything else is even more difficult, since the virus hijacks cellular systems to replicate itself.  Anything that will stop the virus from replicating will badly affect normal cells.

10
Spin Zone / Re: What really is known about COVID19?
« on: September 17, 2020, 11:16:09 AM »
The thing's genome was sequenced and published moths ago.  What is it you want to know, exactly?

11
Spin Zone / Re: so NOW the government cares about the flu?
« on: September 17, 2020, 11:15:19 AM »
The stuff you do token from getting COVID works for influenza as well.  If folks are with the program there won't be much of a flu season this year.

12
Ulcers.  Yep.  A huge pharmaceutical industry dedicated to "turning off the little pumps that make stomach acid that causes ulcers".  The bacterial research was suppressed until enough people were convinced that bacteria caused it.  Driven by another industry that arose to kill ulcer bacteria.

Yeah, it was suppressed for such a long time that it was published immediately and earned the researchers the Nobel Prize.

13
Sadly, I suspect the judge is correct.  Lockdown orders do violate freedom of assembly and a few other things.  If that means the government is powerless to fight the outbreak of disease I feel really badly for us as a nation.

14
I found it in our university library.  I want to be sure this is your paper with 16 authors:
"Extra-embryonic function of Rb is essential for embryonic development and viability".  It was published in "Letters to Nature" which do not appear to be peer reviewed, but I may be mistaken there.  The research looks like it's an extension of existing research.  "... we hypothesized that disruption of Rb itself might also have deleterious consequences in placental development". 

How is this a major result that goes against established research?  You found another factor that might affect placental development.  Yay.  Is there research that says disruption of Rb does NOT affect placental development?

Proteins that fight cancer are called tumor suppressors, and they are big deal in basic science and medicine.  The biggest of them all are P53 and Rb.  Mutations in both cause juvenile cancer syndromes, and both have integral functions within the cell cycle.  Rb functions in the CyclinD/CDK4/E2F axis, and is a very important cell cycle brake.  Knockouts of Rb in mice had suggested that it had widespread functions within the embryo, which made sense for its role as a major tumor suppressor.  I saw some slides of the placenta of an Rb embryo and realized that placental dysfunction was the etiologic agent of most Rb dysfunctions.  This view was not accepted at all at first (I recall my friend Gustavo saying "what's a placenta") but I outlined a research program that would pinpoint Rb's role both in placentogenesis and embryonic function.  It turned out that Rb was only involved in muscle development, most critically the diaphragm.  This was the basis for a multimillion dollar award from the NIH, and was published in Nature.  It overturned a tightly held paradigm, that Rb was essential for numerous embryonic functions.  It was a huge deal, Nature doesn't publish just anything.

The funniest thing is we needed tetraploid rescue to prove the point, and the widget that electrofuses embryos was sitting in a friend's lab across town and he didn't know how to use it.   Quite the surprise.  I got that up and running.  I loved that thing, came from Hungary and you needed a Hungarian darning needle to do the blastomere aggregation experiments.  Good times.

Scientist love new data that overturns paradigms. The old paradigm is once cells are differentiated, they stay that way.  iPS cells put the lie to that, the paper was published in Cell.  Remember ulcers?  Turned out to be a bacterial infection, published in Nature if memory serves.  I could easily go on.  If someone could really prove that there was no climate change, or that it was definitely not caused by humans the journals would eat it up.  If this lady really has data showing that COVID is a product of a bioweapons program she could publish it anywhere. Fact of the matter it isn't.  She's got a lot of nothing, thus she's on Tucker Carlson.

15
Easy to say.  Care to back that up with an example?

Nature. 2003 Feb 27;421(6926):942-7

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